About Our Work
The Gurtner lab encourages translational projects that are developed in the lab and can become commercialized to improved patient care. Dr. Gurtner has multiple patents and has successfully founded two companies from projects initially started in his lab. The lab is located in the heart of the stanford school of medicine providing a unique environment which allows clinical and basic science researchers to work together to tackle ongoing clinical issues. We have multiple collaborations across the hospital, school of medicine and university and interface with industry to facilitate an interdisciplinary approach to our projects. Lab alumni have gone on to pursue careers in various areas of clinical and academic medicine, research and industry.Major funding support is provided by the NIH, NIA, Department of Defense, Clinical Trials and Industry Contracts.
The main research focus of our lab is the study of stem cells and their function in disease models. We utilize novel microfluidic single cell gene expression technology developed by our colleagues at Stanford to better understand stem cell heterogeneity and identify novel subpopulations therein. We are also interested in elucidating how diabetes and aging can affect stem cell function and to studying the specific effect these conditions have on progenitor cell recruitment and function in wound healing.
Another major focus of the lab is Hypertrophic scarring and wound healing. We have recently shown that a protein, focal adhesion kinase, plays a critical role in scar formation, and we are currently developing novel strategies to apply these findings in a clinical setting
Furthermore, in collaboration with Stanford's Biomaterials Department, we have developed a novel biomimetic hydrogel scaffold for stem cell delivery into wounds.
Another focus of the laboratory includes the investigation of complex organ tissue engineering using a bioreactor system. Here, we utilize an expandable free flap as a prevascularized bioscaffold that can be seeded with stem cells on a bioreactor and then re-anastomosed anywhere in the body where needed.
We also have a project in collaboration with Urology to reverse vasectomies using the sutureless anastomosis of vas deferens.